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Depodrol
Methylprednisolone
Description:
Methylprednisolone is a potent anti-inflammatory steroid. It has greater anti-inflammatory potency than Prednisolone, even less tendency than Prednisolone to include sodium and water retention. The relative Potency of Methylprednisolone to Hydrocortisone is at least four to one.
Methylprednisolone is a potent anti-inflammatory steroid. It has greater anti-inflammatory potency than Prednisolone, even less tendency than Prednisolone to include sodium and water retention. The relative Potency of Methylprednisolone to Hydrocortisone is at least four to one.
Indications:
1. Endocrine Disorders: Primary or seconclary adrenocortical insufficiency congenital adrenaI hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.
2. Rheumatic Disorders: Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis and Subacute Bursitis Osteoarthritis, Psoriatic Arthritis etc.
3. Dermatologic Diseases: Bulbous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens - Johnson syndrome).
4. Respiratory Diseases: Symptomatic sarcoidosis, Berylliosis, Aspiration Pneumonitis.
5. Gastrointestinal cliseases: Regional enteritis and ulcerative colitis.
6. Hematologic Disorders: Acquired (autoimmune) hemolytic anemia, idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, congenital hypoplastic anemia.
1. Endocrine Disorders: Primary or seconclary adrenocortical insufficiency congenital adrenaI hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.
2. Rheumatic Disorders: Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis and Subacute Bursitis Osteoarthritis, Psoriatic Arthritis etc.
3. Dermatologic Diseases: Bulbous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens - Johnson syndrome).
4. Respiratory Diseases: Symptomatic sarcoidosis, Berylliosis, Aspiration Pneumonitis.
5. Gastrointestinal cliseases: Regional enteritis and ulcerative colitis.
6. Hematologic Disorders: Acquired (autoimmune) hemolytic anemia, idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, congenital hypoplastic anemia.
Mode of Action:
Methylprednisolone is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostagIandin and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from cell membrane phosphoIipids by phospholipase A2 enzyme.
Methylprednisolone is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostagIandin and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from cell membrane phosphoIipids by phospholipase A2 enzyme.
Different Dosages from Depodrol
Other Brands From Same Therapeutic Class
