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Dionem
Doripenem
Description:
Dionem (Doripenem monohydrate) is a synthetic broad-spectrum carbapenem antibiotic structurally related to beta-lactam antibiotics. Doripenem has potent antibacterial activity against aerobic, anaerobic, Gram-positive and Gram-negative bacteria.
Dionem (Doripenem monohydrate) is a synthetic broad-spectrum carbapenem antibiotic structurally related to beta-lactam antibiotics. Doripenem has potent antibacterial activity against aerobic, anaerobic, Gram-positive and Gram-negative bacteria.
Indications:
Doripenem is specifically indicated for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, pyelonephritis.
Doripenem is specifically indicated for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, pyelonephritis.
Mode of Action:
Doripenem exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Doripenem inactivates multiple essential penicillin-binding proteins (PBPs) resulting in inhibition of cell wall synthesis with subsequent cell death.
Doripenem exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Doripenem inactivates multiple essential penicillin-binding proteins (PBPs) resulting in inhibition of cell wall synthesis with subsequent cell death.
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