Description:
Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis.

Indications:
For the management of:

• Renal tubular acidosis (RTA) with calcium stones
• Hypocitraturic calcium oxalate nephrolithiasis of any etiology
• Uric acid lithiasis with or without calcium stones

Mode of Action:
fter given orally, the metabolism of absorbed citrate produces an alkaline load, which increases urinary pH and urinary citrate. In addition Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium which produces the urine that is less conducive to the crystallization of stone-forming salts (calcium oxalate, calcium phosphate and uric acid). Increased citrate in the urine decreases calcium ion activity and thus the saturation of calcium oxalate. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate (brushite). The increase in urinary pH also decreases calcium ion activity and increases the ionization of uric acid to more soluble urate ion.

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