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Tenoviral
Tenofovir Disoproxil Fumarate
Description:
Tenofovir Disoproxil Fumarate an acyclic nucleotide analog of Adenosine Monophosphate, is a prodrug of Tenofovir.
Tenofovir Disoproxil Fumarate an acyclic nucleotide analog of Adenosine Monophosphate, is a prodrug of Tenofovir.
Indications:
- Chronic Hepatitis B virus infection in adults
- HIV infected adults with others anti-retroviral
Mode of Action:
Tenofovir shows activity against HBV polymerase & HIV reverse transcriptase after phosphorylation of the active diphosphate form. Tenofovir diphosphate inhibits viral polymerase by directly competing with the natural substrate deoxyribonucleotide & by causing DNA chain termination after incorporation into viral DNA.
Tenofovir shows activity against HBV polymerase & HIV reverse transcriptase after phosphorylation of the active diphosphate form. Tenofovir diphosphate inhibits viral polymerase by directly competing with the natural substrate deoxyribonucleotide & by causing DNA chain termination after incorporation into viral DNA.
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