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Lomexa
Lomefloxacin
Description:
Lomefloxacin is a broad spectrum antibiotic of the fluoroquinolone class. Lomefloxacin has in vitro activity against a wide range of Gram-negative and Gram-positive microorganisms and is often bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.
Lomefloxacin is a broad spectrum antibiotic of the fluoroquinolone class. Lomefloxacin has in vitro activity against a wide range of Gram-negative and Gram-positive microorganisms and is often bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.
Indications:
Bacterial infections, including conjunctivitis, keratitis, corneal ulcer, blepharitis and blepharo-conjunctivitis which are due to Lomefloxacin susceptible microorganisms.
Bacterial infections, including conjunctivitis, keratitis, corneal ulcer, blepharitis and blepharo-conjunctivitis which are due to Lomefloxacin susceptible microorganisms.
Mode of Action:
Lomefloxacin interferes with bacterial DNA related processes like replication, transcription, DNA repair, recombination, transposition, supercoiling and relaxation of DNA. The target molecule for quinolones is the A subunit of bacterial enzyme gyrase (topoisomerase II). The forming of a stable complex between the quinolone and the whole gyrase tetramer A2B2 leads to impaired enzyme functions, resulting in a rapid killing of sensitive bacteria.
Lomefloxacin interferes with bacterial DNA related processes like replication, transcription, DNA repair, recombination, transposition, supercoiling and relaxation of DNA. The target molecule for quinolones is the A subunit of bacterial enzyme gyrase (topoisomerase II). The forming of a stable complex between the quinolone and the whole gyrase tetramer A2B2 leads to impaired enzyme functions, resulting in a rapid killing of sensitive bacteria.
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