Description:
The combination of polymyxin B sulphate with neomycin and zinc bacitracin most nearly meets the criteria for an ideal topical antibacterial preparation. Polymyxin B sulphate attacks gram-negative bacilli including clinically-isolated strains of Pseudomonas aeruginosa which is acknowledged to be most effective agent known for the treatment and prophylaxis of Pseudomonas infections. Neomycin provides bactericidal action against various gram-positive organisms and gram-negative organisms including many strains of Proteus. Neomycin is considered by various authorities to be the most effective antibiotic against Staphylococcus aureus which is among the more common aetiological organisms in topical bacterial infections. Zinc bacitracin is highly active against gram-positive bacilli and cocci and extends the spectrum to include haemolytic streptococci, thus completing the anti-bacterial range of Neocin Plus Ointment.

Indications:
Neocin Plus ointment may be used in the treatment of infected wounds, burns or skin grafts, and it is also of value in the preparation of donor sites for skin grafting and in the prevention of infection of extensive burns and contaminated wounds. It is of value in the local treatment of chronic varicose or other indolent ulcers. The preparation is also of value in the treatment of furuncles, carbuncles, pyoderma, sycosis barbae, impetigo and acne. It has also been used in dealing with secondary infected skin lesions of scabies, pediculosis, tinea pedis and contact and allergic dermatitis.

Mode of Action:
Like other aminoglycosides necomycin inhibits bacterial protein synthesis. Bacitracin interferes with bacterial cell wall synthesis by inhibiting the dephosphorylation of a lipid pyrophosphate. Bacitracin inhibits cell wall production by blocking the step in the process (recycling of the membrane lipid carrier) which is needed to add on new cell wall subunits.

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