Description:
Carbamazepine (Cazep®) is an iminodibenzyl derivative with anticonvulsant properties and its structure is related to the tricyclic antidepressants.

Indications:
Epilepsy (All forms of epilepsy except myoclonic and absence seizures), trigeminal neuralgia, mood disorder, aggression and diabetic insipidus.

Mode of Action:
Carbamazepine (Cazep® ) has a wide range of pharmacological effects in animals and humans. The anticonvulsant effects of Carbamazepine are more pronounced against electroshock seizures than against chemically induced seizures. Carbamazepine reduces the generation of high frequency repetitive firing by blocking sodium channels in a use and frequency-dependant manner. This is thought to be its main mode of action, although it also reduces sodium and calcium flux through N-methyl-D-asparate (NMDA)-activated channels at glutamate receptor sites. In addition, it blocks the reuptake of norepinephrine into presynaptic terminals and has adenosine receptor antagonistic effects.

View Details