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Algisum DX
Sodium Alginate BP + Sodium Bicarbonate BP + Calcium Carbonate USP
Description:
Each 10 ml suspension contains Sodium Alginate BP 500 mg, Sodium Bicarbonate BP 213 mg and Calcium Carbonate USP 325 mg.
Each 10 ml suspension contains Sodium Alginate BP 500 mg, Sodium Bicarbonate BP 213 mg and Calcium Carbonate USP 325 mg.
Indications:
Acid regurgitation, heartburn, indigestion and hyperacidity. It can also be used to treat the symptoms of gastroesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy.
Acid regurgitation, heartburn, indigestion and hyperacidity. It can also be used to treat the symptoms of gastroesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy.
Mode of Action:
The mode of action of the product is physical and does not depend on absorption into the systemic circulation. The product is a combination of two antacids (Calcium Carbonate and Sodium Bicarbonate) and an Alginate. On ingestion, the medicinal product reacts rapidly with gastric acid to form a raft of Alginic Acid gel having a near neutral pH and studies have shown that the raft interacts with and caps the acid pocket in the stomach, reducing esophageal acid exposure. The raft floats on the stomach contents effectively impeding gastro-esophageal reflux, for up to 4 hours, and protecting the esophagus from Acid, Pepsin and Bile. In severe cases the raft itself may be refluxed into the esophagus, in preference to the stomach contents and exert a demulcent effect. In addition, in vitro evidence has shown that the raft has a secondary action and is able to entrap bile and pepsin within it's structure, further protecting the esophagus from these gastric components. Calcium Carbonate neutralizes gastric acid to provide fast relief from indigestion and heartburn. This effect is increased by the addition of Sodium Bicarbonate which also has a neutralizing action.
The mode of action of the product is physical and does not depend on absorption into the systemic circulation. The product is a combination of two antacids (Calcium Carbonate and Sodium Bicarbonate) and an Alginate. On ingestion, the medicinal product reacts rapidly with gastric acid to form a raft of Alginic Acid gel having a near neutral pH and studies have shown that the raft interacts with and caps the acid pocket in the stomach, reducing esophageal acid exposure. The raft floats on the stomach contents effectively impeding gastro-esophageal reflux, for up to 4 hours, and protecting the esophagus from Acid, Pepsin and Bile. In severe cases the raft itself may be refluxed into the esophagus, in preference to the stomach contents and exert a demulcent effect. In addition, in vitro evidence has shown that the raft has a secondary action and is able to entrap bile and pepsin within it's structure, further protecting the esophagus from these gastric components. Calcium Carbonate neutralizes gastric acid to provide fast relief from indigestion and heartburn. This effect is increased by the addition of Sodium Bicarbonate which also has a neutralizing action.
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