Description:
Salbutamol BP, the active ingredient of Proventa Inhaler, is a ?2 adrenoceptor agonist used in the treatment of asthma and other forms of diffuse reversible airways obstruction.

Indications:
Proventa (Salbutamol) inhaler is indicated for the treatment and prophylaxis of bronchial asthma and for the treatment of reversible airways obstruction associated with bronchitis and emphysema. Proventa® Inhaler may be used to relieve attacks of acute dyspnoea and may also be taken prophylactically before exertion or to prevent exercise induced asthma. It is suitable for treating bronchospasm in patients with coexisting heart disease or hypertension, including those taking ? blockers, because of its selective action on the bronchial receptors and lack of effects on the cardiovascular system. Salbutamol is a sympathomimetic agent which has a highly selective action on ? adrenergic receptors in bronchial muscle. At therapeutic levels, it has little effect on cardiac receptors.

Mode of Action:
Salbutamol is a selective adrenoceptor agonist with effects on smooth and skeletal muscle. The drug binds with receptor and converts ATP to cyclic-AMP, which activates protein kinase. This leads to phosphorylation of proteins, which ultimately reduces availability of ionized intracellular calcium. The consequent inhibition of actin-myosin linkage causes relaxation of smooth muscle.

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