Description:
Calcium is used as a pharmacologic agent in humans almost entirely to remedy deficiency. Adequate calcium in the blood is so vital to a wide variety of bodily functions that our internal biochemistry will not tolerate a deficiency even for short periods. Vitamin C is an essential component of the diet as man can not synthesize Vitamin C. It is a very powerful reducing agent. Vitamin C plays an important part in the response of the body to stress. It is important in the defense against infection. Vitamin D is a fat-soluble vitamin that helps the body absorb calcium. Fat-soluble vitamins are stored in the body''s fatty tissue

Indications:
As an adjunct to specific therapy for osteoporosis. Increased demand for Calcium, Vitamin C and Vitamin D such as pregnancy, lactation, period of rapid growing (in childhood, addoloscence) and in old age. In osteomalacia. The prevention and treatment of Calcium deficiency/Vitamin D deficiency especially in the housebound and hospitalized elderly subjects. As adjuvant in cold and influenza, Postmenopausal syndromes. Premenstrual symptoms, In high body temperatures, As alkalizing agent in conditions with systemic acidosis

Mode of Action:
Calcium:The major mechanism whereby calcium effects bone is probably through inhibition of PTH secretion. Calcium could alter physical-chemical properties of the bone mineral.Direct effects of calcium on the calcium receptor could also play a role.Vitamin C (Ascorbic acid) plays an important role on maximizing the synthesis of hydroxyproline and deposition of collagen. Vitamin C can also modulates cell differentiation & matrix synthesis, hypertrophic chondrocytes transform osteoblast like cells, increase sulphate incorporation into GAGs.Vitamin D:The active form of vitamin D binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains

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