Description:
Lorix^® Plus is a combination of Permethrin which is a photostable synthetic pyrethroid that possesses a broad spectrum of insecticidal activity and low mammalian toxicity and Crotamiton which is used to treat scabies infection. It is also used to relieve the itching of certain skin conditions.

Indications:
Lorix^® Plus (Permethrin and Crotamiton) lotion is indicated for the treatment of scabies and crab lice infestations (Pediculosis). Besides, it is used for the relief of itching and skin irritation caused by, for example sunburn, dry eczema, itchy dermatitis, allergic rashes, hives, nettle rash, chickenpox, insect bites and stings, heat rashes and personal itching.

Mode of Action:
The insect rapidly absorbs Permethrin via mouth, respiratory tract or the intact cuticle. Although the primary target tissue is the nervous system, insects are not killed by dysfunction of a single organ but by a complex series of reactions in various organs, such as metabolic exhaustion and paralysis of the nervous system. Permethrin primarily affects sodium channels in the nerve membrane and causes prolongation of the transient increase in sodium permeability associated with membrane depolarization. After treatment with permethrin, the sodium current is evoked by a step depolarization of the membrane. This leads to sensory hyperexcitability, incoordination and prostration. It is assumed that mode of action against mites is similar.

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