Description:
Clobetasol Propionate cream, ointment and topical spray is a synthetic corticosteriod for topical dermatologic use.

Indications:
For the topical treatment of moderate to severe plaque psoriasis affecting body surface area and scalp surface.

Mode of Action:
Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

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