Description:
Fusicort Cream combines the potent topical antibacterial activity of fusidic acid with the anti-inflammatory and anti-pruritic activity of the moderately potent corticosteroid hydrocortisone acetate. When applied topically, fusidic acid is effective against Staphylococci, Streptococci, Corynebacteria, Neisseria and certain Clostridia and Bacteroides. The antibacterial activity of fusidic acid is not diminished in the presence of hydrocortisone.

Indications:
Fusicort is indicated in eczema and dermatitis with secondary infections including atopic dermatitis, allergic and seborrhoeic dermatitis and primary irritant dermatitis

Mode of Action:
Fusidic acid is only effective against gram-positive bacteria such as Streptococcus, Staphylococcus aureus and Corynebacterium minutissimum. The antibacterial action of fusidic acid results from inhibition of bacterial protein synthesis. The drug interferes with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes. Hydrocortisone acetate has antiinflammatory, anti-pruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity is thought to induce phospholipase A2 inhibitor proteins, preventing arachidonic acid release and the biosynthesis of potent mediators of inflammation

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